Selank Structure:
Amino Acid Sequence: Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH2
Molecular Formula: C33Hs7N11Og
Molecular Weight: 751.9 g/mol
PubChem CID: 11765600
CAS Number: 129954-34-3
Synonyms: Selanc, TP-7, UNII- TS9JR8EP1G
N-Acetyl Selank Amidate is best thought of as an enhanced version of Selank. Research has shown that N-Acetyl Selank Amidate improves on every aspect of Selank by increasing its potency, half-life, absorbability, and the ease with which it crosses the blood-brain barrier.
The Purpose of N-Acetylation:
N-Acetyl Selank Amidate is similar in its effects to Selank, as already discussed, so it begs the question of why go to the trouble of modifying the original compound. N-acetylation is a common modification found in natural peptides, particularly peptides in eukaryotes. In fact, most proteins in our bodies are N-acetylated. In yeast and humans, N-acetylation has multiple roles including
. Altering protein-protein interactions,
. Subcellular localization,
. Changing the 3-dimensional folding of proteins
. Altering degradation rates.