Epithalon (also known as Epitalon, Epithalone or Epithalamin) is a short synthetic peptide known to activate the telomerase enzyme and stimulate melatonin release. First developed in Russia in the 1980s, epithalon has been shown to delay age-related changes in reproductive and immune systems and increase the life span of mice and rats.
Epithalon Structure:
Source: PubChem
Sequence: Ala-Glu-Asp-Gly
Molecular Formula: C14H22N4Og
Molecular Weight: 390.349 g/mol
PubChem CID: 219042
CAS Number: 307297-39-8
Epithalon (also known as Epitalon, Epithalone or Epithalamin) is a short synthetic peptide known to activate the telomerase enzyme and stimulate melatonin release. First developed in Russia in the 1980s, epithalon has been shown to delay age-related changes in reproductive and immune systems and increase the life span of mice and rats. Though it is primarily of interest in anti-aging research, epithalon has shown significant effects in certain types of cancer, infectious disease, and in DNA regulation.
As stated above, epithalon has a positive effect on the gene that regulates MMP2. MMP2 is a protein found in connective tissue like skin. Research in rodents indicates that not only does epithalon activate this gene, it activates fibroblasts, the cells that produce and maintain MMP2 as well as other components of the extracellular matrix like collagen and elastin. Mice exposed to epithalon show an increase in fibroblast activation of 30 -45%. By activating fibroblasts, epithalon can help to boost rates of healing and offset the natural decline in skin structure and integrity that occurs with aging.