MK-677, also known as Ibutamoren and Oratrope, is an orally active, selective agonist of the ghrelin receptor. Research has shown that MK-677 increases the secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), but does not affect cortisol levels. It is being researched as a possible treatment for growth hormone deficiency, muscle and bone wasting, appetite stimulation and Alzheimer's disease.
MK-677 Structure:
Molecular Formula: C27H36N4O5S
Molecular Weight: 528.7 g/mol
PubChem CID: 9939050
CAS Number: 159634-47-6
Synonyms: MK-0677, Oratrope, lbutamoren, L-163,191
MK-677, also known as Ibutamoren and Oratrope, is an orally active, selective agonist of the ghrelin receptor. Research has shown that MK-677 increases the secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), but does not affect cortisol levels. It is being researched as a possible treatment for growth hormone deficiency, muscle and bone wasting, appetite stimulation and Alzheimer's disease.
MK-677 is often grouped with the selective androgen receptor modulators (SARMs) because it doesn't fit neatly into any other category. MK-677 is not a SARM, however. It also isn't a peptide. It is best described as a complex, synthetic chemical propanamide derivative that acts as a ghrelin receptor agonist. Though it is not a peptide, MK-677 best fits into the growth hormone secretagogue family of peptides if considering effects. Like GHRP-2, GHRP-6, hexarelin, and ipamorelin, MK-677 binds to the ghrelin/growth hormone secretagogue receptor and boosts GH
release while maintaining normal physiologic, pulsatile patterns of GH fluctuation.